Table 1.
Baseline Characteristics of the Study Population by Time‐Averaged On‐Treatment SBP Categories*
| Variables | Time‐Averaged On‐Treatment SBP Categories, mm Hg | P Value | |||
|---|---|---|---|---|---|
| <120 | 120 to <130 | 130 to <140 | ≥140 | ||
| No. | 263 | 2658 | 5878 | 6179 | |
| Age, y | 58.1±7.4 | 58.8±7.2 | 59.7±7.4 | 60.9±7.4 | <0.001 |
| Men, n (%) | 99 (37.6) | 1042 (39.2) | 2500 (42.5) | 2469 (40.0) | 0.005 |
| Body mass index, kg/m2 | 24.6±3.5 | 24.6±3.5 | 24.8±3.6 | 25.1±3.7 | <0.001 |
| Current smoking, n (%) | 43 (16.3) | 543 (20.4) | 1432 (24.4) | 1517 (24.6) | <0.001 |
| Current alcohol drinking, n (%) | 39 (14.9) | 581 (21.9) | 1481 (25.2) | 1482 (24.0) | <0.001 |
| Family history of diabetes mellitus, n (%) | 13 (4.9) | 89 (3.4) | 244 (4.2) | 207 (3.4) | 0.056 |
| Enalapril group, n (%) | 139 (52.9) | 1332 (50.1) | 2907 (49.5%) | 3124 (50.6) | 0.514 |
| BP, mm Hg | |||||
| SBP at baseline | 147.6±16.1 | 156.0±16.3 | 163.6±17.1 | 175.6±21.2 | <0.001 |
| DBP at baseline | 90.2±10.5 | 92.1±10.7 | 93.5±11.2 | 96.0±12.7 | <0.001 |
| Time‐averaged on‐treatment SBP | 117.1±2.7 | 126.3±2.7 | 135.1±2.8 | 148.6±7.7 | <0.001 |
| Time‐averaged on‐treatment DBP | 76.4±4.8 | 79.4±5.6 | 81.9±6.2 | 85.4±7.9 | <0.001 |
| Laboratory results, mmol/L | |||||
| Total cholesterol | 5.3±1.1 | 5.4±1.1 | 5.5±1.1 | 5.5±1.2 | <0.001 |
| Triglycerides | 1.4 (1.0–1.2) | 1.4 (1.0–1.9) | 1.4 (1.0–1.9) | 1.4 (1.0–1.2) | <0.001 |
| Fasting glucose, mg/dL | 95.2±11.7 | 95.6±12.0 | 96.9±12.4 | 97.9±12.6 | <0.001 |
| Creatinine, μmol/L | 66.4±16.7 | 65.2±15.7 | 66.2±16.1 | 65.7±17.2 | 0.056 |
| Folate, ng/mL | 8.1 (5.8–10.4) | 8.2 (5.6–10.7) | 8.0 (5.6–10.3) | 7.9 (5.5–10.3) | 0.003 |
| Medication use, n (%) | |||||
| Antihypertensive drugs | 122 (46.4) | 1205 (45.3) | 2602 (44.3) | 2959 (47.9) | <0.001 |
| Lipid‐lowering drugs | 1 (0.4) | 28 (1.1) | 44 (0.7) | 40 (0.6) | 0.202 |
| Antiplatelet drugs | 10 (3.8) | 74 (2.8) | 174 (3.0) | 191 (3.1) | 0.749 |
BP indicates blood pressure; DBP, diastolic blood pressure; and SBP, systolic blood pressure.
*
Continuous variables are presented as mean±SDs or medians (25th percentile–75th percentile). Categorical variables are presented as n (%).