Table 2.
Association Between Time‐Averaged On‐Treatment Blood Pressure and Incident Diabetes Mellitus
| BP, mm Hg | n | No. of Events (%) | Crude Model | Adjusted Model* | ||
|---|---|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |||
| Time‐averaged on‐treatment SBP | ||||||
| <120 | 263 | 23 (8.7) | 1.20 (0.76‒1.88) | 0.435 | 1.25 (0.78‒1.99) | 0.358 |
| 120 to <130 | 2658 | 197 (7.4) | Ref. | Ref. | ||
| 130 to <140 | 5878 | 606 (10.3) | 1.44 (1.21‒1.70) | <0.001 | 1.37 (1.15‒1.64) | <0.001 |
| ≥140 | 6179 | 802 (13.0) | 1.86 (1.58‒2.19) | <0.001 | 1.67 (1.39‒2.00) | <0.001 |
| Time‐averaged on‐treatment DBP | ||||||
| <70 | 491 | 42 (8.6) | 0.80 (0.57‒1.11) | 0.172 | 0.76 (0.53‒1.07) | 0.117 |
| 70 to <80 | 4788 | 504 (10.5) | Ref. | Ref. | ||
| 80 to <90 | 7434 | 814 (10.9) | 1.05 (0.93‒1.18) | 0.461 | 1.13 (0.98‒1.30) | 0.090 |
| ≥90 | 2265 | 268 (11.8) | 1.14 (0.97‒1.34) | 0.101 | 1.30 (1.06‒1.61) | 0.012 |
| P for trend | 0.031 | 0.003 | ||||
| Time‐averaged on‐treatment SBP/DBP | ||||||
| <130 and <80 | 1603 | 125 (7.8) | Ref. | Ref. | ||
| 130 to <140 and/or 80 to <90 | 6618 | 651 (9.8) | 1.29 (1.06‒1.58) | 0.012 | 1.24 (1.00‒1.53) | 0.047 |
| ≥140 and/or ≥90 | 6757 | 852 (12.6) | 1.71 (1.40‒2.08) | <0.001 | 1.54 (1.24‒1.92) | <0.001 |
BP indicates blood pressure; DBP, diastolic blood pressure; OR, odds ratio; and SBP, systolic blood pressure.
*
Adjusted for age, sex, study center, body mass index, smoking, family history of diabetes mellitus, systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol, triglycerides, creatinine, folate, and the use of antihypertensive drugs at baseline, as well as use of calcium channel blockers or diuretics during the treatment period.