Table 4.
Change in Optical Coherence Tomography Findings
| Control Group (n=31) | EPA Group (n=31) | EPA+DHA Group (n=35) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | Follow‐Up | P Value | Baseline | Follow‐Up | P Value | Baseline | Follow‐Up | P Value | |
| Minimal FCT, μm | 130 (70–190) | 160 (100–250) | 0.0121 | 120 (70–160) | 150 (120–210) | 0.0029 | 100 (60–150) | 200 (130–260) | <0.0001 |
| Maximal lipid arc, ° | 202.5 (162.2–234.4) | 165.9 (137.9–196.9) | 0.0003 | 176.9 (149.5–247.3) | 159.0 (121.1–241.4) | 0.0079 | 175.2 (138.4–218.2) | 157.9 (127.2–213.4) | 0.0141 |
| Average lipid arc, ° | 152.0 (125.5–164.3) | 144.4 (127.6–171.3) | 0.4790 | 150.9 (121.6–185.7) | 153.7 (113.3–207.6) | 0.9522 | 147.6 (122.2–195.1) | 134.0 (103.9–183.7) | 0.9522 |
| Lipid length, mm | 4.6 (2.8–7.4) | 4.4 (2.8–7.0) | 0.5440 | 4.2 (2.4–5.6) | 3.6 (2.4–5.0) | 0.0016 | 3.4 (2.2–5.6) | 2.8 (2.0–4.4) | 0.0107 |
| Lipid volume index | 766.0 (435.2–1148.8) | 723.8 (360.4–1017.0) | 0.5051 | 626.6 (462.4–932.6) | 558.9 (317.2–835.6) | 0.0484 | 462.1 (355.7–876.8) | 384.2 (225.1–735.4) | 0.0119 |
| Macrophage infiltration | 28 (90) | 27 (87) | 0.5722 | 27 (87) | 25 (81) | 0.1607 | 33 (94) | 30 (86) | 0.083 |
| Cholesterol crystal | 8 (26) | 8 (26) | 1.000 | 3 (10) | 1 (3)*, * | 0.1607 | 6 (17) | 6 (17) | 1.000 |
| Microchannel | 6 (19) | 6 (19) | 1.000 | 5 (16) | 4 (13) | 0.3253 | 6 (17) | 6 (17) | 1.000 |
| Plaque rupture | 3 (10) | 3 (10) | 1.000 | 1 (3) | 1 (3) | 1.000 | 0 (0) | 0 (0) | 1.000 |
Values are presented as median (interquartile interval) or n (percentage). DHA indicates docosahexaenoic acid; EPA, eicosapentaenoic acid; and FCT, fibrous cap thickness.
*
P<0.05 vs control group at follow‐up.