Table 2.
β‐Coefficient (95% CI) of Global Perivascular Space Score With Vascular Risk Factors and APOE ε4 Allele
| Vascular Risk Factors and APOE Genotype | β‐Coefficient (95% CI), Global Perivascular Space Score | |
|---|---|---|
| Model 1* | Model 2* | |
| Ever smoking | 0.25 (−0.64 to 1.13) | 0.08 (−0.83 to 0.98) |
| Physical inactivity | 0.35 (−0.73 to 1.44) | 0.36 (−0.75 to 1.47) |
| Overweight or obesity (body mass index ≥25 kg/m2) | 0.30 (−0.57 to 1.16) | 0.40 (−0.48 to 1.28) |
| Hypertension | 0.74 (−0.29 to 1.77) | 0.51 (−0.54 to 1.56) |
| Blood pressure, mm Hg | ||
| <120/80 | 0.57 (−2.29 to 1.15) | 0.47 (−2.21 to 1.27) |
| 120 to 139/80 to 89 | 0.00 (reference) | 0.00 (reference) |
| 140 to 159/90 to 99 | 0.50 (−0.58 to 1.59) | 0.44 (−0.66 to 1.54) |
| ≥160/100 | 1.30 (0.06 to 2.53) † | 1.03 (−0.24 to 2.30) |
| Uncontrolled high blood pressure (≥150/90 mm Hg) | 0.79 (−0.09 to 1.67) | 0.57 (−0.33 to 1.47) |
| Orthostatic hypotension | 0.47 (−0.62 to 1.55) | 0.21 (−0.90 to 1.33) |
| Systolic blood pressure ≥160 mm Hg | 1.46 (0.20 to 2.72) † | 1.29 (0.01 to 2.58) † |
| Diastolic blood pressure ≥100 mm Hg | 2.33 (0.49 to 4.16) † | 1.80 (−0.14 to 3.75) |
| High total cholesterol (≥6.22 mmol/L) | 0.20 (−0.67 to 1.07) | 0.29 (−0.59 to 1.18) |
| Diabetes mellitus | −1.32 (−2.96 to 0.31) | −1.37 (−3.10 to 0.35) |
| APOE ε4 allele | −0.33 (−1.34 to 0.67) | −0.52 (−1.54 to 0.49) |
| High CRP (>5 mg/L) | −0.92 (−2.06 to 0.21) | −0.76 (−1.91 to 0.39) |
CRP indicates C‐reactive protein.
*
Model 1 was adjusted for age, sex, education, and cardiovascular disease, and model 2 was additionally adjusted for white matter hyperintensities.
†
P<0.05.