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. 2020 May 12;9(10):e014257. doi: 10.1161/JAHA.119.014257

Figure 3. Flow‐dependent carotid remodeling in Npr2 mice.

Figure 3

A, Representative 3‐dimensional (3D) reconstructions of the 2‐mm length from the bifurcation of the LCA after sham or ligation operation in males of Npr2 wild‐type (Npr2 +/+) and Npr2 heterozygous (Npr2 +/−) mice. B, Representative 3D reconstructions of LCA after sham or ligation operation in females of Npr2 +/+ and Npr2 +/− mice. Black indicates lumen, yellow indicates intima, red indicates media, and green indicates adventitia volume. C, Quantifications of LCA intima/media ratio, adventitia, and EEL volume in males of Npr2 +/+ and Npr2 +/− mice. D, Quantifications of LCA intima/media ratio, adventitia, and EEL volume in females of Npr2 +/+ and Npr2 +/− mice. Open circles indicate individual sham LCAs. Black circles indicate ligated LCAs. Gray lines indicate mean values. EEL indicates external elastic lamina; and LCA, left carotid artery. *P<0.05 vs sham; † P<0.05 vs Npr2 +/+ males; ‡ P<0.05 vs Npr2 +/− females. n=3 to 6 per group.