Table 2.

Relationship Between Integrated Care and Major Adverse Events

	ABC Adherent vs Non‐ABC Adherent
	Univariate Analysis		Multivariate Analysis
	HR (95% CI)	P Value	HR (95% CI)	P Value
Multimorbiditya
Composite outcome	0.60 (0.43–0.83)	0.002	0.61 (0.44–0.85)	0.004
Hospitalization	0.61 (0.44–0.85)	0.004	0.62 (0.45–0.87)	0.006
All‐cause death	0.22 (0.06–0.88)	0.033	0.23 (0.06–0.94)	0.041
Cardiovascular events	0.53 (0.34–0.83)	0.005	0.54 (0.35–0.84)	0.007
Any event	0.59 (0.42–0.82)	0.002	0.60 (0.43–0.84)	0.003
Polypharmacyb
Composite outcome	0.67 (0.46–0.98)	0.038	0.68 (0.47–1.00)	0.053
Hospitalization	0.68 (0.45–0.99)	0.042	0.69 (0.46–1.01)	0.058
All‐cause death	0.50 (0.16–1.56)	0.23	0.49 (0.16–1.54)	0.22
Cardiovascular events	0.66 (0.41–1.06)	0.087	0.67 (0.41–1.08)	0.099
Any event	0.66 (0.45–0.97)	0.033	0.68 (0.46–0.99)	0.045
Hospitalizationc
Composite outcome	0.59 (0.41–0.83)	0.003	0.59 (0.42–0.85)	0.004
Hospitalization	0.57 (0.40–0.82)	0.003	0.58 (0.40–0.84)	0.004
All‐cause death	0.51 (0.19–1.36)	0.18	0.49 (0.18–1.33)	0.16
Cardiovascular events	0.48 (0.30–0.76)	0.002	0.48 (0.30–0.77)	0.002
Any event	0.58 (0.41–0.83)	0.002	0.59 (0.41–0.84)	0.003

ABC indicates Atrial fibrillation Better Care; AF, atrial fibrillation; and HR, hazard ratio.

^aMultivariate analysis adjusted for age, sex, first AF episode, use of aspirin.

^bMultivariate analysis adjusted for age, sex, first AF episode, diabetes mellitus, hepatic/renal disease, pulmonary disease.

^cMultivariate analysis adjusted for age, sex, first AF episode, diabetes mellitus, hepatic/renal disease, pulmonary disease, use of aspirin.