Table 2.
TMAO Quartiles Definition | 1st Quartile (N=452) (Range 0.12–3.24 μmol/L) | 2nd Quartile (N=450) (Range 3.25–4.75 μmol/L) | 3rd Quartile (N=450) (Range 4.76–7.20 μmol/L) | 4th Quartile (N=451) (Range 7.22–157.37 μmol/L) | P for Trend |
---|---|---|---|---|---|
Odds ratios for primary end point (cardiovascular death, MI, and stroke) | |||||
Number of cases (%) | 138 (30.5) | 141 (31.3) | 152 (33.8) | 166 (36.8) | |
Matcheda | Ref | 1.03 (0.78–1.37, P=0.81) | 1.19 (0.89–1.59, P=0.24) | 1.43 (1.06–1.93, P=0.02) | 0.015 |
Odds ratios for cardiovascular death | |||||
Number of cases (%) | 23 (5.1) | 30 (6.7) | 38 (8.4) | 48 (10.6) | |
Adjustment for matching variableb | Ref | 1.32 (0.75–2.34, P=0.34) | 1.68 (0.97–2.93, P=0.067) | 2.25 (1.28–3.96, P=0.005) | 0.003 |
Odds ratios for recurrent MI | |||||
Number of cases (%) | 108 (23.9) | 101 (22.4) | 101 (22.4) | 102 (22.6) | |
Adjustment for matching variableb | Ref | 0.94 (0.68–1.30, P=0.70) | 1.09 (0.79–1.51, P=0.60) | 1.10 (0.79–1.55, P=0.57) | 0.42 |
Odds ratios for stroke | |||||
Number of cases (%) | 15 (3.3) | 19 (4.2) | 31 (6.9) | 41 (9.1) | |
Adjustment for matching variableb | Ref | 1.25 (0.62–2.52, P=0.52) | 2.05 (1.07–3.93, P=0.031) | 2.68 (1.39–5.17, P=0.003) | <0.001 |
The trend P value was calculated by testing the coefficient of an ordinal TMAO variable from the logistic regression model. eGFR indicates estimated glomerular filtration rate; MI, myocardial infarction; and TMAO, trimethylamine N‐oxide.
Conditional (matched) logistic regression was used for the primary end point with matching variables (age, sex, eGFR).
Unconditional (unmatched) logistic regression was used for each individual component cardiovascular death, MI, and stroke events adjusting for matching variables (age, sex, eGFR).