Table 3.
Risk of PRU for MACCE (PRU=208) and Major Bleeding Events (PRU=85) Through 1‐Year Follow‐Up According to ACS or Non‐ACS
| Event Rates at 1 y | LPR vs OPR | HPR vs OPR | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| LPR | OPR | HPR | Unadjusted HR (95% CI) | P Value | Adjusted HR (95% CI) | P Value | Unadjusted HR (95% CI) | P Value | Adjusted HR (95% CI) | P Value | |
| MACCEa | |||||||||||
| ACS | 3.4% (10/297) | 4.5% (42/942) | 7.1% (44/620) | 0.75 (0.38–1.50) | 0.415 | 0.88 (0.40–1.92) | 0.749 | 1.61 (1.06–2.46) | 0.027 | 1.72 (1.05–2.82) | 0.031 |
| Non‐ACS | 2.4% (9/380) | 3.0% (61/2060) | 4.5% (73/1607) | 0.80 (0.40–1.61) | 0.533 | 0.58 (0.25–1.35) | 0.206 | 1.55 (1.11–2.18) | 0.011 | 1.45 (1.00–2.09) | 0.048 |
| Major bleedingb | |||||||||||
| ACS | 2.4% (7/297) | 2.8% (26/942) | 3.2% (20/620) | 0.85 (0.37–1.95) | 0.698 | 0.90 (0.33–2.43) | 0.836 | 1.17 (0.65–2.10) | 0.594 | 1.55 (0.81–2.96) | 0.188 |
| Non‐ACS | 3.2% (12/380) | 2.1% (43/2060) | 2.9% (46/1607) | 1.54 (0.81–2.91) | 0.190 | 1.61 (0.82–3.17) | 0.166 | 1.39 (0.92–2.11) | 0.120 | 1.31 (0.83–2.07) | 0.251 |
ACS indicates acute coronary syndrome; HPR, high P2Y12 reaction unit; HR, hazard ratio; LPR, low P2Y12 reaction unit; MACCE, major adverse cardiac and cerebrovascular events; OPR, optimal P2Y12 reaction unit; and PRU, P2Y12 reaction unit.
a
Variables entered in this model include sex, age, body weight, smoking, and composite of prior myocardial infarction, prior percutaneous coronary intervention, and prior coronary artery bypass graft surgery.
b
Variables entered in this model include sex, age, body weight, smoking, and composite of history of cerebral hemorrhage and gastrointestinal hemorrhage.