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. 2020 Nov 2;16(11):e1009176. doi: 10.1371/journal.pgen.1009176

Fig 8. CRISPR activation screens in HeLa and MCF10A cells to identify genes that result in resistance to multiple ATRi when overexpressed.

Fig 8

(A) Diagram showing the overlap of identical genes within the top hits of the ATRi activation screens in HeLa cells with logP values lower than -2.0. (B) Diagram showing the overlap of identical genes within the top hits of the ATRi activation screens in MCF10A cells with logP values lower than -2.0. (C) The number of common genes within the top hits with logP values lower than -2.0 (namely 50 for the HeLa screens and 43 for the MCF10A screens) is much higher than the random probability of identical hits. (D, E) Tables listing the common genes among top 40 hits in each of the ATRi CRISPR activation screens in HeLa (D) and MCF10A (E) cells.