Table 3. Results of inferring the causal direction between HDL and CAD after combining across all 8 SNPs in 6 loci.

Method	HDL → CAD			CAD → HDL
	$\widehat{K}$ [95% CI]	${\widehat{b}}_0$ (SE)	$\widehat{K}$ [95% CI]	${\widehat{b}}_0$ (SE)
CD-Ratio	-0.441 [−0.498, −0.385]	NA	-0.842 [−0.979, −0.706]	NA
CD-Egger	-0.445 [−0.685, −0.205]	-0.001 (0.003)	-1.414 [−2.174, −0.654]	-0.001 (0.006)
CD-GLS	-0.444 [−0.674, −0.215]	-0.001 (0.003)	-1.334 [−2.035, −0.634]	-0.001 (0.006)