Table 4. Results of bi-rectional MR for the causal relationship between HDL and CAD by various MR methods.

Each cell gives “$\widehat{\beta }$ (SE), p-value”.

Causality	IVW	Egger	Weighted Median	Weighted Mode	RAPS
HDL→CAD	-0.281(0.058),	-0.197(0.096),	-0.085(0.052),	-0.083(0.061),	-0.301(0.053),
	1 × 10−6	0.041	0.100	0.176	1.4 × 10−8
CAD→HDL	-0.0823(0.033),	-0.104(0.084),	-0.032(0.015),	-0.027(0.014),	-0.089(0.033),
	0.013	0.225	0.029	0.061	0.006