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. 2020 Oct 26;9:e55865. doi: 10.7554/eLife.55865

Table 2. Genes the contributed to the core-enrichment of the GSEA.

Probe Description Rank Gene list Rank Metric score Core enrichment UPR branch
ASNS Asparagine synthetase (glutamine-hydrolyzing) [Source:HGNC Symbol;Acc:HGNC:753] 207 0.940 Yes Perk
PPP2R5B Protein phosphatase two regulatory subunit B'beta [Source:HGNC Symbol;Acc:HGNC:9310] 423 0.821 Yes Ire1a
CCL2 C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] 847 0.689 Yes Ire1a and Perk
EXOSC9 Exosome component 9 [Source:HGNC Symbol;Acc:HGNC:9137] 1004 0.654 Yes Ire1a and Perk
WIPI1 WD repeat domain, phosphoinositide interacting 1 [Source:HGNC Symbol;Acc:HGNC:25471] 1022 0.649 Yes Ire1a
KDELR3 KDEL endoplasmic reticulum protein retention receptor 3 [Source:HGNC Symbol;Acc:HGNC:6306] 1106 0.635 Yes Ire1a
SHC1 SHC adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:10840] 2691 0.432 Yes Ire1a
TPP1 Tripeptidyl peptidase 1 [Source:HGNC Symbol;Acc:HGNC:2073] 2884 0.414 Yes Ire1a
HDGF Heparin binding growth factor [Source:HGNC Symbol;Acc:HGNC:4856] 3235 0.386 Yes Ire1a
TLN1 Talin 1 [Source:HGNC Symbol;Acc:HGNC:11845] 3264 0.384 Yes Ire1a
EXTL3 Exostosin like glycosyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:3518] 3488 0.365 Yes Ire1a
TSPYL2 TSPY like 2 [Source:HGNC Symbol;Acc:HGNC:24358] 3680 0.350 Yes Ire1a
MBTPS1 Membrane-bound transcription factor peptidase, site 1 [Source:HGNC Symbol;Acc:HGNC:15456] 3996 0.327 Yes Atf6
PDIA5 Protein disulfide isomerase family A member 5 [Source:HGNC Symbol;Acc:HGNC:24811] 4530 0.294 Yes Ire1a
DCTN1 Dynactin subunit 1 [Source:HGNC Symbol;Acc:HGNC:2711] 4638 0.287 Yes Ire1a
DNAJC3 DnaJ heat-shock protein family (Hsp40) member C3 [Source:HGNC Symbol;Acc:HGNC:9439] 4761 0.281 Yes Ire1a
SULT1A4 Sulfotransferase family 1A member 4 [Source:HGNC Symbol;Acc:HGNC:30004] 4938 0.272 Yes Ire1a
PARN Poly(A)-specific ribonuclease [Source:HGNC Symbol;Acc:HGNC:8609] 5037 0.266 Yes Perk
ADD1 Adducin 1 [Source:HGNC Symbol;Acc:HGNC:243] 5375 0.250 Yes Ire1a
ERN1 Endoplasmic reticulum to nucleus signaling 1 [Source:HGNC Symbol;Acc:HGNC:3449] 5411 0.248 Yes Ire1a