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SPLIS with mineral deposition and edema. T2-FLAIR axial MR images of a 4-year-old child with SPLIS show involvement of the dentate nuclei (A), cerebral peduncles and tectum (B), and globi pallidi (C). There is surrounding edema. Loss of central signal is attributed to calcium on the basis of the analysis of susceptibility-weighted images in another patient. The findings predominantly involve dopaminergic neurons.
