Table 3.
Genotype and allele frequencies of TLR2 GT repeat inPemphigus foliaceus patient's groups and their relative matched healthy controls.
| Group 1 ♀ age of onset under 35 years |
Group 2 ♀♂ age of onset above 35 years |
Group 3 Endemic localities |
Group 4 Nonendemic localities |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case N = 55 (%) |
Controls N = 83 (%) |
P
OR, 95% CI |
Case N = 38 (%) |
Controls N = 110 (%) |
P
OR, 95% CI |
Case N = 37 (%) |
Controls N = 69 (%) |
P
OR, 95% CI |
Case N = 56 (%) |
Controls N = 124 (%) |
P
OR, 95%CI |
|
| TLR2>(GT)n | ||||||||||||
| 12 | 2 (1.9) | 4 (4.9) | 0.2 | 2 (3.4) | 3 (1.8) | 0.5 | 1 (1.4) | 5 (6) | 0.1 | 3 (3.2) | 1 (0.6) | 0.1 |
| 13 | 7 (6.7) | 4 (4.9) | 0.6 | 5 (8.6) | 5 (3.1) | 0.09 | 6 (8.5) | 3 (3.6) | 0.2 | 6 (6.5) | 6 (3.8) | 0.3 |
| 14 | 0 | 1 (1.2) | — | 0 | 1 (0.6) | — | 0 | 1 (1.2) | — | 0 | 1 (0.6) | 0.4 |
| 15 | 0 | 0 | — | 0 | 1 (0.6) | — | 0 | 0 | — | 0 | 1 (0.6) | 0.4 |
| 16 | 1 (0.9) | 1 (1.2) | 0.8 | 0 | 5 (3.1) | — | 1 (1.4) | 4 (4.8) | 0.2 | 0 | 2 (1.2) | 0.27 |
| 17 | 3 (2.8) | 4 (4.9) | 0.45 | 5 (8.6) | 10 (6.3) | 0.5 | 1 (1.4) | 5 (6) | 0.1 | 7 (7.6) | 9 (5.8) | 0.58 |
| 18 | 28 (26.9) | 16 (19.9) | 0.27 | 13 (22.4) | 28 (17.7) | 0.4 | 24 (34.2) | 15 (18.2) | 0.02 2.3 [1.1-4.9] |
17 (18.4) | 29 (18.8) | 0.9 |
| 19 | 25 (24) | 21 (26..2) | 0.7 | 14 (24.1) | 30 (18.9) | 0.4 | 21 (30) | 14 (17) | 0.059 | 18 (19.5) | 37 (24) | 0.5 |
| 20 | 12 (11.5) | 10 (12.4) | 0.8 | 7 (12) | 16 (10.5) | 0.6 | 8 (11.4) | 5 (6) | 0.2 | 11 (11.9) | 21 (13.6) | 0.7 |
| 21 | 8 (7.6) | 3 (3.7) | 0.26 | 1 (1.7) | 17 (10.7) | 0.03 | 4 (5.7) | 12 (14.6) | 0.07 | 5 (5.4) | 8 (5.1) | 0.9 |
| 22 | 4 (3.8) | 4 (4.9) | 0.7 | 2 (3.4) | 9 (5.6) | 0.5 | 1 (1.4) | 3 (3.6) | 0.4 | 5 (5.4) | 10 (6.4) | 0.7 |
| 23 | 11 (10.5) | 11 (13.7) | 0.5 | 6 (10.3) | 22 (13.9) | 0.48 | 3 (4.2) | 13 (15.8) | 0.02 0.2 [0.06-0.87] |
14 (15.2) | 19 (12.3) | 0.5 |
| 24 | 1 (0.9) | 0 | — | 2 (3.4) | 4 (2.5) | 0.7 | 0 | 1 (1.2) | — | 3 (3.2) | 3 (1.9) | 0.5 |
| 25 | 1 (0.9) | 1 (1.2) | 0.8 | 1 (1.7) | 5 (3.1) | 0.56 | 0 | 1 (1.2) | — | 2 (2.1) | 5 (3.2) | 0.6 |
| 26 | 1 (0.9) | 0 | — | 0 | 2 (1.2) | 0.38 | 0 | 0 | — | 1 (1) | 2 (1.2) | 0.7 |
| GT18/GT19 | 12 (23) | 2 (4.9) | 0.16 | 6 (20.6) | 6 (7.5) | 0.054 | 12 (34.2) | 1 (2.4) | 2.3 10−4 20 [2.5-171] |
6 (13) | 7 (11) | 0.5 |
| GT18/GT20 | 5 (9.6) | 0 | 0.043 | 3 (10.3) | 2 (2.5) | 0.08 | 5 (10.8) | 1 (1.2) | 0.017 | |||
| 18 ≤ Gn ≤ 22 | 77 | 54 | 0.47 | 37 | 100 | 0.9 | 58 | 49 | 0.0018 3.26 [1.5-7] |
56 | 105 | 0.052 |
| GTn ≤ 17 GTn ≥ 23 |
27 | 25 | 21 | 58 | 12 | 33 | 36 | 49 | ||||
This case control-study enrolled 93 PF patients matched to 193 healthy control, whereas in some subjects the genotyping was failed.