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. 2020 Nov 12;17:338. doi: 10.1186/s12974-020-01979-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Predicted daily LCP initiator levels in SAH patients with or without the development of DCI. Predicted daily levels of ficolin-1, ficolin-2, ficolin-3, and MBL in CSF (left) and in plasma (right) in patients with (blue) or without (red) the development of DCI. The predicted daily levels are presented as medians in CSF and as means in plasma. Error bars show 95% confidence intervals. P values shown in the bottom left of each graph are adjusted for confounders (age, sex, WFNS, and Fisher score) and multiple testing (Benjamini-Hochberg procedure) and represent the overall difference in concentration between groups (p-adj) and overall different development over time (p-adj_interaction) for each LCP initiator. Asterisks indicate (*) significant levels on specific days <0.05. Each LCP initiator graph is based on a total number of 241 CSF samples from 36 SAH patients (mean number of samples per patient, 7; range, 6–8) and 233 plasma samples from 33 SAH patients (mean number of samples per patient, 7; range, 6–8). LCP: Lectin complement pathway, MBL: Mannose-binding lectin, CSF: Cerebrospinal fluid, CT: Computed tomography, DCI: Delayed cerebral ischemia, SAH: Subarachnoid hemorrhage