Table 2.

Overall difference in CSF levels of each LCP initiator in SAH subgroups (DCI and functional outcome)

	Univariate analyses			Multivariate analyses (age, sex, WFNS, Fisher)
CSF-levels	Estimate (95% CI)	p	p-adj	Estimate (95% CI)	p	p-adj
DCI
Ficolin-1  (ng/mL)	1.87 (0.99, 3.53)	0.052	0.20	1.72 (0.85, 3.48)	0.12	0.48
Ficolin-2  (μg/mL)	1.08 (0.73, 1.60)	0.69	0.69	1.11 (0.70, 1.78)	0.64	0.64
Ficolin-3  (μg/mL)	1.26 (0.75, 2.13)	0.37	0.61	1.20 (0.65, 2.23)	0.55	0.64
MBL  (ng/mL)	1.21 (0.49, 1.39)	0.46	0.61	0.78 (0.42, 1.47)	0.43	0.64
Functional outcome
Ficolin-1  (ng/mL)	1.85 (1.12, 3.05)	0.017*	0.022*	1.87 (1.17, 2.99)	0.010*	0.040*
Ficolin-2  (μg/mL)	1.47 (1.08, 2.01)	0.015*	0.022*	1.33 (0.96, 1,83)	0.079	0.10
Ficolin-3  (μg/mL)	1.54 (1.01, 2.36)	0.043*	0.043*	1.45 (0.92, 2.27)	0.10	0.10
MBL  (ng/mL)	1.69 (1.13, 2.52)	0.012*	0.022*	1.69 (1.09, 2.63)	0.020*	0.040*

Estimates represent the relative overall difference in CSF concentration (relative ∆medians) of each LCP initiator in patients with DCI versus without DCI (reference) and in patients with a poor versus good (reference) functional outcome, respectively. Both univariate linear mixed model analyses (left) and multivariate analyses (right) with adjustment for confounders are shown in the table.

P values (p) represent the overall difference in CSF concentrations between groups (assuming no interaction). p-adj represent p values corrected for multiple testing using Benjamini-Hochberg’s procedure. Asterisks indicate significance levels <0.05.

∆: Difference; CI confidence interval, CSF cerebrospinal fluid, Fisher: extent and location of the intracranial hemorrhage, LCP lectin pathway initiators, MBL mannose-binding lectin; WFNS: clinical severity on admission