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. 2020 Nov 12;21:737. doi: 10.1186/s12891-020-03706-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Identification of optimal cutoff values of age of diagnosis via X-tile analysis. a The vertical axis represents all possible high OS populations, with the size of the high OS population increasing from top to bottom. The horizontal axis represents all possible low OS populations, with the size of the low OS population increasing from left to right. Coloration of the plot represents the strength of the association at each division, ranging from low (dark, black) to high (red). b Kaplan-Meier survival curves of three age groups. c The histogram of three age groups

OS, overall survival.