Fig. 2.

Rno-miR-183-5p and rno-miR-210-3p inhibited the luciferase activity of wild-type SIN3A through binding to its 3′ UTR (a–f Luciferase assay, N = 3, *p value < 0.05, vs control group). Rno-miR-183-5p and rno-miR-210-3p mimics suppressed the expression of SIN3A in SH-SY5H cells (g–l Real-time PCR and Western blot analysis; Technical repeats n = 3; *p value < 0.05, vs. scramble control group). a The luciferase activity of wild-type SIN3A was inhibited by rno-miR-183-5p. b Rno-miR-34c-3p showed no inhibitory effect on the luciferase activities of wild-type and mutant SIN3A. c The luciferase activity of wild-type SIN3A was inhibited by rno-miR-210-3p. d Rno-miR-758-5p showed no inhibitory effect on the luciferase activities of wild-type and mutant SIN3A. e Rno-miR-568 showed no inhibitory effect on the luciferase activities of wild-type and mutant SIN3A. f Rno-miR-196c-3p showed no inhibitory effect on the luciferase activities of wild-type and mutant SIN3A. g The expression of SIN3A was inhibited by rno-miR-183-5p in SH-SY5H cells. h Rno-miR-34c-3p showed no repressive effect on the SIN3A expression in SH-SY5H cells. i The expression of SIN3A was inhibited by rno-miR-210-3p in SH-SY5H cells. j Rno-miR-758-5p showed no repressive effect on the SIN3A expression in SH-SY5H cells. k Rno-miR-568 showed no repressive effect on the SIN3A expression in SH-SY5H cells. l Rno-miR-196c-3p showed no repressive effect on the SIN3A expression in SH-SY5H cells