Table 9.
Risks associated with discouraging participation in HIV cure research
| Very likely to discourage N (%) |
Somewhat likely to discourage N (%) |
Not likely to discourage N (%) |
Not discouraging N (%) |
DNK N (%) |
DNA N (%) |
Missing N (%) |
|
| Toxicities/adverse side effects | 35 (30) | 12 (10) | 14 (12) | 3 (3) | 17 (14) | 10 (9) | 27 (23) |
| Potential for drug resistance development | 31 (26) | 11 (9) | 13 (11) | 5 (4) | 19 (16) | 15 (13) | 24 (20) |
| Potential for virus returning if ART is stopped | 31 (26) | 9 (8) | 7 (6) | 5 (4) | 25 (21) | 14 (12) | 27 (23) |
| Activation of cancer-causing genes | 27 (23) | 5 (4) | 13 (11) | 3 (3) | 28 (24) | 14 (12) | 28 (24) |
| GVHD | 29 (25) | 8 (7) | 9 (8) | 3 (3) | 28 (24) | 12 (10) | 29 (25) |
| Invasive study procedures | 25 (21) | 10 (9) | 7 (6) | 9 (8) | 20 (17) | 12 (10) | 35 (30) |
| Long-term follow-up for safety and outcomes | 28 (24) | 12 (10) | 10 (9) | 8 (7) | 24 (20) | 10 (9) | 26 (22) |
| Neurological side effects | 23 (20) | 18 (15) | 10 (9) | 5 (4) | 17 (14) | 16 (14) | 29 (25) |
| Gastrointestinal side effects | 26 (22) | 17 (14) | 10 (9) | 7 (6) | 18 (16) | 15 (13) | 25 (21) |
| Psychological side effects | 29 (25) | 17 (14) | 9 (8) | 7 (6) | 17 (14) | 13 (11) | 26 (22) |
| HIV-related side effects | 33 (28) | 14 (12) | 8 (7) | 7 (6) | 20 (17) | 15 (13) | 21 (18) |
| Dermatological side effects | 37 (31) | 14 (12) | 5 (4) | 6 (5) | 21 (18) | 13 (11) | 22 (19) |
| Musculoskeletal side effects | 33 (28) | 15 (13) | 9 (8) | 6 (5) | 15 (13) | 14 (12) | 26 (22) |
| Allergic reactions | 29 (25) | 13 (11) | 11 (9) | 3 (3) | 15 (13) | 17 (14) | 30 (25) |
| Risk of giving HIV to sexual partners | 32 (27) | 10 (9) | 11 (9) | 2 (2) | 18 (15) | 13 (11) | 32 (27) |
| Unknown side effects | 26 (22) | 11 (9) | 6 (5) | 3 (3) | 22 (13) | 19 (16) | 31 (26) |
| Pain or discomfort | 28 (24) | 13 (11) | 4 (3) | 3 (3) | 21 (18) | 19 (16) | 30 (25) |
| Having to stay in hospital overnight | 18 (16) | 12 (10) | 10 (9) | 12 (10) | 19 (16) | 19 (16) | 28 (24) |
| Taking time away from family | 19 (16) | 13 (11) | 12 (10) | 9 (8) | 14 (12) | 23 (20) | 28 (24) |
| Taking time away from work | 20 (17) | 11 (9) | 11 (9) | 12 (10) | 16 (14) | 20 (17) | 28 (24) |
| Long study visits (4+ hours) | 22 (19) | 11 (9) | 12 (10) | 11 (9) | 17 (14) | 19 (16) | 26 (22) |
DNA, does not apply; DNK, do not know.