Table 6.

Most frequent clinical manifestations of PPGLs and their distribution

Adapted from Mannelli M, et al. Pheochromocytoma in Italy: A multicentric retrospective study. Eur J Endocrinol. 1999;141:619–24 [37]

Signs and symptoms
Sustained or paroxysmal HT	80–90%
Palpitations and tachycardia	58%
Headaches	52%
Sweating attacks	49%
Anxiety and panic attacks	35%
Tremors	26%
Nausea	22%
Dyspnea	17%
Abdominal pain	16%
Vertigo	16%
Parasthesiae	12%
Chest pain	12%
Weakness	11%
Diarrhea/constipation	5%
Fever	2%
Other suggestive conditions  Paradoxical response to some precipitating drugs  Dilated cardiomyopathy  Erythrocytosis, hyperglycemia, hypercalcemia  Adrenal incidentaloma, with or without HT  Hereditary predisposition or syndromic features suggesting hereditary PPGLs

HT hypertension