Table 7.

Signs and symptoms associated with Cushing’s syndrome and their prevalence

Adapted from Nieman LK, et al. The diagnosis of Cushing’s syndrome: An endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2008;93:1526–40 [39]

Decreased libido	91–100%
Facial rounding (“moon faces”)
Obesity
Impaired glucose tolerance/diabetes	71–90%
Menstrual changes
Hirsutism
Striae rubre
Muscle weakness	51–70%
Osteopenia/osteoporosis/fractures
Psychiatric disturbances (especially lethargy, depression)
Atherosclerosis
Easy bruising
Impaired wound healing
Headaches
Backache	21–50%
Recurrent infections
Edema
Hypokalemic alkalosis
Acne	11–20%
Hair loss