Table 2.

Measured outcomes for comparing tacrolimus trough levels before, during, and after flucloxacillin treatment

Parameter	Before flucloxacillin	During flucloxacillin	After flucloxacillin
Mean blood trough level/dose, μg/L/mg (± SD)	2.3 (± 1.6)* n = 10	1.3 (± 1.0)	1.9 (± 1.3)
Median blood trough level/dose, μg/L/mg(min-max)	2.3 (0.52–3.77)	1.3 (0.3–3.3)	1.5 (0.5–3.8)
Median blood trough level/dose ratios before/during and after/during flucloxacillin (min-max)	–	1.6 (0.6–3.1)	1.7 (0.7–3.0)
Median blood trough level/dose ratios before/during and after/during flucloxacillin, percentage (IQR)	–	− 37.5 (26.4–49.7)	+ 33.7 (22.5–51.4)
Mean ratio before/during and after/during flucloxacillin treatment (± SD)	–	1.7 (± 0.7)	1.5 (± 0.7)

*n = 11 unless otherwise specified. The mean/median blood trough levels/dose before flucloxacillin treatment consists of the mean/median of the available tacrolimus trough levels up to 1 year before flucloxacillin treatment, divided by the dose at time of trough concentration sampling. The mean/median blood trough levels/dose during flucloxacillin treatment consists of all available tacrolimus trough levels during flucloxacillin treatment starting from the day after start of flucloxacillin treatment until the last day of flucloxacillin treatment. The mean/median tacrolimus trough levels/dose after flucloxacillin treatment consists of all the available trough levels divided by dose starting from 1 day after discontinuation of flucloxacillin up to 1 year after discontinuation of flucloxacillin