Table 1.
Pharmacokinetic parameters of midazolam following single dose of midazolam 5 mg alone and with multiple dose of lusutrombopag
| Parameter (N = 15) | Midazolam alone | Midazolam + lusutrombopag | GLS mean ratioa (90% CI) |
|---|---|---|---|
| Cmax (ng/mL) | 23.8 (25.1) | 24.1 (27.7) | 1.01 (0.908, 1.13) |
| Tmax (h)b | 0.50 (0.50, 1.00) | 0.75 (0.50, 1.00) | - |
| AUC0–last (ng h/mL) | 58.7 (28.6) | 61.0 (31.0) | 1.04 (0.975, 1.11) |
| AUC0–inf (ng h/mL) | 63.0 (28.4) | 64.9 (32.5)c | 1.04 (0.967, 1.11) |
| λz (h−1) | 0.165 (39.4) | 0.186 (54.9)c | - |
| t½,z (h) | 4.21 (39.4) | 3.74 (54.9)c | - |
| CL/F (L/h) | 79.4 (28.4) | 77.0 (32.5)c | - |
-, not calculated; CI, confidence interval; GLS, geometric least squares
Geometric mean (% coefficient of variation) except for Tmax. Median (minimum, maximum) for Tmax
aGLS mean ratio (coadministration with lusutrombopag/midazolam alone)
bMedian (minimum, maximum)
cn = 14