Table 3.
Major study outcomes
| Median OS (months) | Median PFS (months) | Overall response rate (%) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Trial | Statin group | Control group | HR (95% CI), p value | Statin group | Control group | HR (95% CI), p value | Statin | Control | p value |
| Alexandre et al. [21] | NS | NS | HR 1.56 (0.14-17.28), p = 0.716 | NS | NS | HR 0.78 (0.11-5.61), p = 0.807 | NS | NS | NS |
| Jouve et al. [22] | 10.7 (7.7–14.3) | 10.5 (8.2–12.4) | 1.00 (0.79–1.28), p = 0.975 | 5.0 (3.4–6.0) | 4.4 (3.3–5.6) | 1.00 (0.80–1.25), p = 0.986 | NS | NS | NS |
| Lee et al. [23] | 10.0 (6.4–13.8) | 7.0 (6.1–7.9) | 1.03 (0.58–1.80), p = 0.466 | 1.0 (0.5–1.4) | 3.6 (3.0–4.1) | 1.38 (0.84–2.29), p = 0.898 | 5.70% | 9.40% | 0.43 |
| Seckl et al. [24] | 10.7 | 10.6 | 1.01 (0.88–1.16), p = 0.90 | 7.7 | 7.3 | 0.98 (0.85–1.13), p = 0.81 | 69% | 69.10% | 0.963c |
| El-Hamamsy et al. [25] | 3.4 (0.69–6.01) | 3 (2.46–3.54) | NS, p = 0.880 | 1.6 (0.68–2.52) | 1.47 (0.91–2.02) | NS, p = 0.392 | 78.6%b | 60%b | 0.427 |
| Lim et al. [26] | 15.3 (12.1–18.5) | 19.2 (16.8–21.6) | NS, p = 0.826a | 5.9 (4.5–7.3) | 7 (5.4–8.6) | 1.03 (0.77–1.37), p = 0.858 | 11.90% | 11.80% | 1 |
| Kim et al. [27] | 11.6 (9.2–13.9) | 11.5 (9.9–13.1) | NS, p = 0.818 | 5.2 (4.3–6.1) | 4.6 (3.5–5.7) | 0.93 (0.68–1.26), p = 0.664 | 27.50% | 29.00% | 0.936 |
| Hong et al. [28] | 6.6 (4.4–8.2) | 8.7 (4.8–12.6) | NS, p = 0.98 | 2.4 (0.7–4.1) | 3.6 (3.1–4.1) | NS, 0.903 | 6.90% | 14.30% | 0.23 |
| Han et al. [29] | 13.6 (7.1–20.1) | 12 (7.8–16.2) | 0.88 (0.57–1.35), p = 0.491 | 3.3 (1.4–5.2) | 1.9 (1.0–2.8) | 0.891 (0.60–1.32), p = 0.549 | 38.50% | 31.50% | 0.666 |
| Konings et al. [30] | 8 (3.02–12.98) | 6 (4.93–7.08) | NS | 6 (3.39–8.61) | 5 (3.83–6.17) | NS | 33.30% | 46.70% | 0.473 |
| Kawata et al. [31] | 18 | 9 | 0.42 (0.20–0.83), p = 0.006 | NS | NS | NS | NS | NS | NS |
NS not stated, OS overall survival, PFS progression-free survival
Figures in parenthesis indicate 95% confidence intervals
ap value calculated using log-rank test
bRadiological response
cp value calculated using chi-squared test
Figures in parenthesis indicate 95% confidence intervals