Fig. 4.

Teduglutide influences structural hypertrophy. a Representative H.E. sections through jejunal villi. Scale bar represents 50 µm. b Villus length at day 0 and day 14. In wt animals, villus length was significantly increased by resection in vehicle-treated animals (day 0 vs. day 14: 204 ± 9.0 µm, n = 13 vs. 293 ± 13.0 µm, n = 11, p < 0.05, unpaired t test, mean ± SEM). Under Teduglutide treatment, villus length was even further increased (day 14 vehicle vs. Teduglutide: 293.1 ± 13.0 µm, n = 11 vs. 337 ± 21.3 µm, n = 12, p < 0.05, unpaired t test, mean ± SD). c Bowel diameter at day 0 and day 14. Bowel diameter was unaffected by Teduglutide treatment (2351 ± 295 µm, n = 10 vs. 2352 ± 146 µm, n = 7, p > 0.05, unpaired t test, mean ± SD)