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. 2020 Feb 19;65(12):3521–3537. doi: 10.1007/s10620-020-06140-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 7 — Teduglutide promotes paracellular cation size selectivity in the SBS jejunum in wt mice. a Cation size selectivity in the jejunum is characterized by a size cutoff between 2 and 3 Å, which was detectable at day 0 in wt animals. In the adapted jejunum (d14 vehicle), this size cutoff seemed reduced. In contrast, under Teduglutide treatment, this size cutoff was preserved. Mean ± SEM. b In Nod2 k.o. animals, the tight junction size cutoff was similar to wt animals. At day 14, the size cutoff seemed lost in vehicle-treated animals but also in Teduglutide-treated animals. c Relative Na/Cl permeability in wt animals. P_Na/P_Cl was not significantly different between d0 and d14 (mean ± SD, p > 0.05, unpaired t test). Teduglutide treatment significantly increased P_Na/P_Cl (mean ± SD, p < 0.05, unpaired t test). d Relative Na/Cl permeability in Nod2 k.o. animals. P_Na/P_Cl was significantly lower at d14 compared to d0 (mean ± SD, p < 0.05, unpaired t test). Teduglutide had no effect on P_Na/P_Cl in Nod2 k.o. animals (mean ± SD, p > 0.05, unpaired t test)