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. 2020 Oct 30;8:586541. doi: 10.3389/fcell.2020.586541

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Copyright © 2020 He, Liu, Huang, Zhuo, Chen, Duan, Tang, Lu and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Olfactory mucosa mesenchymal stem cell (OM-MSC) injection reduced the cerebral infarction volume and alleviated neurologic deficits in ischemia/reperfusion (I/R) rats. (A,B) The infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining (n = 3 animals per group). (C,D) The line charts show the results of the modified neurologic severity score (mNSS; n = 12 animals per group) and rotarod treadmill (n = 12 animals per group). Data are shown as the mean ± SEM. *p ≤ 0.05, ***p < 0.001, compared with the sham group and ^&p ≤ 0.05, ^&&p < 0.01, and ^&&&p < 0.001, compared with the I/R group.