Table 1.

Significantly over- and under-represented D. melanogaster Sfp classes, and matched human Sfp classes, determined using PANTHER [41]. p-values are FDR (false discovery rate)-corrected and values <0.05 are italicised. We have indicated whether the direction and significance of enrichment matches between the species.

PANTHER protein classes	D. melanogaster over/under	D. melanogaster fold enrichment	D. melanogaster FDR-corrected p-value	human direction same? yes/no	human significance same? yes/no	human over/under	human fold enrichment	human FDR-corrected p-value
protease inhibitor (PC00191)	+	11.33	0.000	yes	yes	+	4.5	0.000
defence/immunity protein (PC00090)	+	16.8	0.000	no	no	−	0.73	0.217
protease (PC00190)	+	2.99	0.000	yes	yes	+	2.48	0.000
lipase (PC00143)	+	8.02	0.000	yes	no	+	1.49	0.493
serine protease (PC00203)	+	4.13	0.000	yes	yes	+	2.23	0.000
hydrolase (PC00121)	+	3.17	0.000	yes	yes	+	2.65	0.000
protein-binding activity modulator (PC00095)	+	2.81	0.006	yes	yes	+	1.88	0.000
protein-modifying enzyme (PC00260)	+	1.81	0.038	yes	yes	+	1.71	0.000
apolipoprotein (PC00052)	+	13.33	0.042	yes	no	+	1.68	0.523
gene-specific transcriptional regulator (PC00264)	−	<0.01	0.002	yes	yes	−	0.15	0.000
nucleic acid-binding protein (PC00171)	−	0.09	0.004	yes	yes	−	0.52	0.000
DNA-binding transcription factor (PC00218)	−	<0.01	0.004	yes	yes	−	0.14	0.000
RNA-binding protein (PC00031)	−	0.11	0.041	yes	yes	−	0.36	0.000
transporter (PC00227)	−	0.19	0.045	yes	no	−	0.88	0.616