Table 2.

Subgroup analyses.

Subgroups	VAS			DAS28			Serum vitamin D			TJC			SJC			ESR			CRP			PTH
	WMD	95% CI	P	WMD	95% CI	P	WMD	95% CI	P	WMD	95% CI	P	WMD	95% CI	P	WMD	95% CI	P	WMD	95% CI	P	WMD	95% CI	P
Geographical regions
North America	–	–	–	–	–	–	22.26	[−6.97, 51.49]	0.14	–	–	–	–	–	–				–	–	–	−1.00	[−10.19, 8.19]	0.83
Europe	−9.26	[−14.51, −4.00]	0.0006	−0.54	[−0.74, −0.34]	<0.001	20.35	[9.79, 30.91]	0.0002	−0.90	[−2.65, 0.85]	0.31	−0.50	[−1.68, 0.68]	0.41	−3.25	[−8.94, 2.43]	0.26	−0.31	[−3.71, 3.09]	0.86	6.40	[−0.10, 12.90]	0.05
Asia	6.47	[0.13, 12.82]	0.05	0.07	[−0.31, 0.46]	0.71	26.50	[15.98, 37.02]	<0.001	−2.10	[−4.04, −0.16]	0.03	−1.00	[−2.17, 0.17]	0.10	−2.40	[−6.30, 1.50]	0.23	−7.50	[−17.75, 2.75]	0.15	–	–	–
Duration
≤ 12 w	−0.86	[−5.53, 3.82]	0.72	−0.06	[−0.28, 0.17]	0.63	23.37	[16.15, 30.59]	<0.001	−1.44	[−2.74, −0.14]	0.03	−0.75	[−1.58, 0.08]	0.08	−2.44	[−6.14, 1.25]	0.20	−1.04	[−5.07, 2.99]	0.61	3.94	[−1.37, 9.24]	0.15
>12 w	−8.90	[−17.02, −0.78]	0.03	−1.00	[−1.29, −0.71]	<0.001	–	–	–	–	–	–	–	–	–	−3.40	[−9.93, 3.13]	0.31	−1.00	[−6.38, 4.38]	0.72	–	–	–
Vitamin D dose
≤ 50,000 IU	6.47	[0.13, 12.82]	0.05	0.07	[−0.31, 0.46]	0.71	26.01	[16.12, 35.91]	<0.001	−2.10	[−4.04, −0.16]	−0.03	−1.00	[−2.17, 0.17]	0.10	−2.40	[−6.30, 1.50]	0.23	−7.50	[−17.75, 2.75]	0.15	−1.00	[−10.19, 8.19]	0.83
>50,000 IU	−9.26	[−14.51, −4.00]	0.0006	−0.54	[−0.74, −0.34]	<0.001	20.35	[9.79, 30.91]	0.0002	−0.90	[−2.65, 0.85]	0.31	−0.50	[−1.68, 0.68]	0.41	−3.25	[−8.94, 2.43]	0.26	−0.31	[−3.71, 3.09]	0.86	6.40	[−0.10, 12.90]	0.05