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. 2020 Nov 12;10:19689. doi: 10.1038/s41598-020-76712-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolic and cell death analyses after inhibition of renin activity. H9c2 pIRES cells (control vector transfected) and ren(2–9) overexpressing H9c2 cells (renin-b cells) were subjected to 24 h normoxic and anoxic conditions without (white columns) and with renin inhibitor CH732 (grey columns). (a) ATP levels (n = 9), (b) glucose consumption (n = 8), (c) extracellular lactate accumulation (n = 7), (d) necrosis rate (n = 9), (e) percentage of CaspACE-positive cells (n = 7), and (f) percentage of Annexin V-positive cells (n = 7) were measured. All data represent mean ± SEM. Data are analyzed by Two-way ANOVA analysis comparing the effect of renin overexpression, CH732 treatment as well as the effect of anoxia as indicated. *P < 0.05 versus pIRES control. ^#P < 0.05 versus normoxia.