Table 6.
The best diagnostic value of protein expression in DNA repair genes.
| Indicator | Cut-off value | Sensitivity (%) | Specificity (%) | Youden index | AUC | AUC (95% CI) | |
|---|---|---|---|---|---|---|---|
| MSH2 | > 6 | 72.82 | 48.54 | 0.2136 | 0.629 | 0.559 | 0.695 |
| MLH1 | > 9 | 37.86 | 79.61 | 0.1748 | 0.620 | 0.550 | 0.686 |
| PARP1 | > 6 | 76.70 | 79.61 | 0.5631 | 0.833 | 0.775 | 0.881 |
| XRCC1 | > 6 | 67.96 | 74.76 | 0.4272 | 0.771 | 0.707 | 0.826 |
| XRCC4 | > 6 | 78.64 | 79.61 | 0.5825 | 0.834 | 0.776 | 0.882 |
| 53BP1 | > 4 | 84.47 | 45.63 | 0.3010 | 0.688 | 0.620 | 0.750 |
| ERCC1 | > 3 | 89.32 | 50.49 | 0.3981 | 0.744 | 0.679 | 0.802 |
| XPA | > 9 | 25.24 | 95.15 | 0.2039 | 0.634 | 0.565 | 0.700 |