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. 2020 Nov 12;10:19738. doi: 10.1038/s41598-020-76778-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cellular accumulation and distribution patterns of developed NPs in A549 and NIH3T3 cells. (A) Cellular uptake data of Dil-loaded NPs in A549 and NIH3T3 cells analyzed by flow cytometry. Cell count values according to the fluorescence intensity of control, PLGA/Dil NPs, DOX@PLGA NPs, DOX@PLGA/Dil NPs, and DOX@PLGA/Dil NPs + SA groups are shown. Mean fluorescence intensity values of all experimental groups are plotted. Each point indicates the mean ± SD (n = 3). ^/p < 0.05, compared with PLGA/Dil NPs group. ^#p < 0.05, compared with DOX@PLGA NPs group. ^&p < 0.05, compared with DOX@PLGA/Dil + SA NPs group. (B) Intracellular fluorescence signals of developed NPs in A549 and NIH3T3 cells observed by CLSM imaging. DAPI, red, and merged images of control, PLGA/Dil NPs, DOX@PLGA NPs, DOX@PLGA/Dil NPs, and DOX@PLGA/Dil NPs + SA groups are shown. The length of scale bar in the image is 20 μm.