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. 2020 Nov 12;10:19738. doi: 10.1038/s41598-020-76778-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cytotoxicity tests in A549 cells. Cell viability profiles according to PHL, DOX, and PLGA NPs concentrations are shown. Antiproliferation potentials of PLGA/PHL NPs, DOX@PLGA NPs, and DOX@PLGA/PHL NPs at 1, 2.5, and 5 μg/ml PHL concentrations are exhibited. Each point indicates the mean ± SD (n = 3). ^*p < 0.05, compared with PLGA/PHL NPs group. ^#p < 0.05, compared with DOX@PLGA NPs group.