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. 2020 Nov 12;10:19738. doi: 10.1038/s41598-020-76778-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tumor penetration capability and anticancer activity tests of developed NPs in A549 multicell spheroid model. (A) Tumor infiltration efficacy test of Dil-loaded NPs in A549 spheroid model. 2D (merged), 2D (red), and 3D (merged) images of control, PLGA/Dil NP, DOX@PLGA NPs, DOX@PLGA/Dil NPs, and DOX@PLGA/Dil NPs + SA groups are shown. The length of scale bar in the image is 50 μm. (B) Spheroid images after applying live/dead assay and ROS assay reagents observed by CLSM imaging. Merged images of control, PLGA/PHL NPs, DOX@PLGA NPs, and DOX@PLGA/PHL NPs are shown. The length of scale bar in the image is 50 μm.