Table 4.

Comparison of toxicity parameters between N,O acetal derivatives from 2-amino-1,4-naphthoquinone and antimalarial (atovaquone) and antibacterial drugs.

Drug	Toxicity
	Oral rat acute toxicity (LD50)	Oral rat chronic toxicity (LOAEL)	hERG I	hERG II	Hepatotoxicity	Toxicological endpoint
	Numeric (mol/kg)	Numeric (log mg/kg.bw/day)	Categorical (Yes/No)			Immunotoxicity	Carcinogenicity	Cytotoxicity	Mutagenicity
						Categorical (Active/Inactive)
6a	1.776	2.776	No	No	No	Inactive	Active	Inactive	Active
7a	2.136	2.512	No	No	No	Active	Active	Inactive	Active
7b	2.192	2.503	No	No	No	Inactive	Inactive	Inactive	Active
7c	2.158	2.553	No	No	No	Active	Active	Inactive	Inactive
Atovaquone	2.327	2.009	No	Yes	No	Inactive	Inactive	Inactive	Inactive
Cefoxitin	1.544	2.909	No	No	Yes	Inactive	Inactive	Inactive	Inactive
Ciprofloxacin	2.891	1.036	No	No	Yes	Inactive	Inactive	Active	Inactive
Doxorubicin	2.408	3.339	No	Yes	Yes	Active	Inactive	Active	Active
Furazolidone	2.645	1.355	No	No	No	Inactive	Active	Inactive	Active
Nitrofurantoin	2.565	1.390	No	No	No	Inactive	Active	Inactive	Active
Tetracycline	2.214	3.038	No	No	No	Active	Inactive	Inactive	Inactive
Vancomycin	2.482	9.212	No	Yes	Yes	Active	Inactive	Inactive	Inactive