Fig. 2.

Structural effects of intra-articular Invossa (TissueGene-C (TissueGene Inc., Rockville, MD, USA)) in moderate to advanced knee osteoarthritis. Axial intermediate-weighted fat-suppressed MRI in treated patient at baseline (a) and 12 months (b) follow-up show improvement of cartilage focal defect and thickness of the medial patella (long arrows). Also note the decrease in volume of the joint effusion (small arrows). Guermazi, A., Kalsi, G., Niu, J. et al. Structural effects of intra-articular TGF-β1 in moderate to advanced knee osteoarthritis: MRI-based assessment in a randomized controlled trial. BMC Musculoskelet Disord 18, 461 (2017). 10.1186/s12891-017-1830-8. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited