TABLE 3.
Event rates in the REDUCE‐IT trial 21 and the REDUCE‐IT‐Like and REDUCE‐IT‐Excluded subgroups in the FAST‐MI 2010 and 2015 registries
| Outcome, per 1000 patient‐years (95% CI) | REDUCE‐IT trial patients | FAST‐MI 2010 + 2015 | ||
|---|---|---|---|---|
| Established CVD (n = 5785) | Diabetes mellitus + risk factor for CVD (n = 2394) | REDUCE‐IT‐Excluded (n = 3317) | REDUCE‐IT‐Like (n = 472) | |
| Composite outcome | 36.9 (26.1‐51.0) a | 20.7 (13.0‐32.1) a | 31.1 (27.8‐34.8) b | 36.7 (27.8‐48.6) b |
| Total death | 18.7 (11.4‐29.7) | 12.1 (6.2‐21.0) | 19.4 (17.0‐22.1) | 24.3 (17.7‐33.4) |
| Nonfatal myocardial infarction | 20.4 (12.2‐30.9) | 8.8 (4.1‐17.1) | 6.9 (5.4‐8.7) | 9.1 (5.2‐16.0) |
| Nonfatal stroke | 6.3 (2.2‐13.1) | 4.9 (1.6‐11.7) | 2.8 (1.9‐4.1) | 2.2 (0.7‐7.0) |
Abbreviations: CI, confidence interval; CVD, cardiovascular disease; FAST‐MI, French registry on acute ST‐elevation and non‐ST‐elevation myocardial infarction; REDUCE‐IT, reduction of cardiovascular events with icosapent ethyl‐intervention trial.
a
Cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke for REDUCE‐IT.
b
All‐cause death, nonfatal myocardial infarction, or nonfatal stroke for FAST‐MI.