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. 2020 Nov 12;10:19656. doi: 10.1038/s41598-020-72355-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Endocytosis of EVs results in intracellular Aβ deposits in cortical neurons. TEM analysis indicated that EVs attached to and were endocytosed by cortical neurons (asterisks, a). The process of EV uptake by the neurons could also be monitored with time-lapse microscopy (asterisk, b). Immunocytochemistry followed by confocal microscopy, confirmed intracellular Aβ deposits in Aβ₄₂ protofibril-EV exposed neurons (c). Scale bars: (b) = 10 µm and (c) = 20 µm.