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. 2020 Nov 12;10:19657. doi: 10.1038/s41598-020-75013-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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VH gene family usage in PTECs differs from that in B cells. (a) The VH gene family usage of PTECs differs significantly from that of B cells, especially higher percentage of VH1 in PTECs (****, p < 0.0001). The DH (b) and JH (c) gene family usage of PTECs are similar to those of B cells, except for lower percentage of JH3 in PTECs (*, p < 0.05). Chi-square test was used to compare the frequency of VH, D, JH usage between PTECs and B cells. (d) Distribution of the expressed VH genes of PTECs and B cells on the IgG heavy chain locus. Here, PTECs show a restricted distribution at the 3′ end compared to that of B cells, which express more widely distributed VH genes.