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Comparisons of disease activity between ACPA-negative [ACPA (−)] and ACPA-positive [ACPA (+)] groups. (A) Transition of mean SDAI score. (B) Mean change from baseline in SDAI score. ACPA anti-citrullinated protein/peptide antibody, SDAI simplified disease activity index. *p < 0.05, **p < 0.01, Student’s t-test, compared with ACPA (−) group. †p < 0.05, ††p < 0.01, paired t-test, comparisons between each time point.
