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Categorical distribution of disease activity defined by SDAI score in ACPA-negative [ACPA (−)] and ACPA-positive [ACPA (+)] groups. ACPA anti-citrullinated protein/peptide antibody, SDAI simplified disease activity index, HDA high disease activity, MDA moderate disease activity, LDA low disease activity, REM remission. *p < 0.05, **p < 0.01 in LDA achievement rate, chi-square test. ††p < 0.01 in LDA achievement rate, chi-square test, compared with ACPA (−) group.
