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. 2020 Nov 12;10:19717. doi: 10.1038/s41598-020-76842-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparisons of disease activity indices that are components of the SDAI score. ACPA anti-citrullinated protein/peptide antibody, SDAI simplified disease activity index, TJC tender joint count, SJC swollen joint count, PtGA patient’s global assessment, PhGA physician’s global assessment, CRP C-reactive protein. *p < 0.05, **p < 0.01, Student’s t-test, compared with ACPA (−) group at each time point.