Table 2.
Expression levels of angiotensin-converting enzyme 2 (ACE2), transmembrane protease, serine 2 (TMPRSS2), and related transcription factors in different tissues.
| ACE2 and related transcription factors | TMPRSS2 and related transcription factors | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Tissue | ACE2 | C/EBPβ | NF-AT1 | GRα | VDR | RXRα | XBP1 | TMPRSS2 | GCF | AP-2α | PAX5 |
| Gastrointestinal and Proximal Digestive Tract | High | Moderate | Moderate | High | High | High | Moderate | High | Moderate | High | Moderate |
| Lung | Low | Moderate | Moderate | High | Low | High | Moderate | Moderate | Moderate | N/A | Low |
| Bone marrow, Lymphoid tissues, Thyroid gland | Low | High | High | High | Low | High | Moderate | Moderate | High | Moderate | High |
| Kidney and urinary bladder | Moderate | Moderate | Moderate | High | Low | High | Low | High | Moderate | N/A | Low |
| Liver and gall bladder | Moderate | Low | N/A | High | N/A | N/A | Moderate | Moderate | High | N/A | Low |
| Skin | Low | High | N/A | High | Low | High | Low | Low | High | High | Low |
| Male tissues | Moderate | N/A | Low | High | Low | High | Moderate | High | Moderate | Moderate | Low |
| Muscle tissue | N/A | Moderate | Moderate | High | Low | High | Low | N/A | High | N/A | Low |
The level of expression was determined by normalized expression levels from three transcriptome datasets (HPA, GTEx, and FANTOM5). Tissues that are not relevant to COVID-19 are not noted.