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. 2020 Oct 30;11:587725. doi: 10.3389/fmicb.2020.587725

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Copyright © 2020 Ariyoshi, Hagihara, Eguchi, Fukuda, Iwasaki, Oka, Takahashi, Yamagishi and Mikamo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clindamycin (CLDM) induces prostaglandin production from linoleic acid via arachidonic acid (AA). The metabolic pathway is centered on AA. The signal intensities of the metabolites were compared using the average value of each group. The vertical axis indicates the signal intensity. Enzymes used for the metabolism of each lipid are indicated in bold (n = 3). HpETE, Hydroperoxyeicosatetraenoic acid; HETE, Hydroxyeicosatetraenoic acid; COX, Cyclooxygenase; LOX, Lipoxygenase; CYP450, Cytochrome P450. *p < 0.05 and **p < 0.01 compared with control.