TABLE 2.

The pathogenicity of the somatic mutations in spinal schwannoma by SIFT, PolyPhen-2, and MutationTaster.

Gene Symbol	Effect	Transcript:exon:CDS	SIFT	Polyphen2-HDIV	Polyphen2-HVAR	Mutation Taster	Sample	VAF
ATM	Non-sense	NM_000051:exon46:c.C6725A:p.S2242X	NA	NA	NA	D	CHG004878	0.13
ATM	Missense	NM_000051:exon60:c.T8699C:p.L2900P	D	D	D	D	CHG004882	0.13
ATM	Missense	NM_000051:exon24:c.T3458C:p.V1153A	T	B	B	N	CHG004884	0.10
CHD4	Missense	NM_001297553:exon9:c.C1460T	T	D	B	D	CHG004878	0.13
CHD4	Missense	NM_001297553:exon18:c.G2831A:p.G944E	D	D	D	D	CHG004884	0.34
FAT1	Non-sense	NM_005245:exon2:c.G370T:p.E124X				A	CHG004880	0.14
FAT1	Missense	NM_005245:exon10:c.C6110T:p.T2037M	D	B	B	N	CHG004888	0.18
KMT2D	Missense	NM_003482:exon34:c.G9484A:p.G3162S	D	B	B	N	CHG004878	0.10
KMT2D	Missense	NM_003482:exon48:c.G15713A:p.R5238Q	T	D	P	D	CHG004892	0.14
MED12	Missense	NM_005120:exon3:c.C385A:p.L129I	D	D	D	D	CHG004886	0.25
MED12	Missense	NM_005120:exon28:c.G4037A:p.R1346H	D	P	B	D	CHG004890	0.25
NF2	Missense	NM_181830:exon14:c.G1517A:p.C506Y	D	D	D	D	CHG004880	0.22
NF2	Non-sense	NM_181830:exon10:c.C979T:p.Q327X				A	CHG004884	0.50
NF2	Inframe deletion	NM_181830:exon6:c.513_557del:p.171_186del	NA	NA	NA	NA	CHG004880	0.53
SUFU	Missense	NM_001178133:exon10:c.C1177T:p.R393W	D	D	D	D	CHG004880	0.49
SUFU	Missense	NM_001178133:exon6:c.G691A:p.G231S	D	D	D	D	CHG004886	0.11

D, deleterious; P, probably deleterious; B, benign; T, tolerant; A, disease causing automatic; N, polymorphism; NA, not available.