Figure 3.

Wedelolactone, a non-selective IKKα/β inhibitor of the alternative or non-canonical NF-κB signaling pathway (A), but not SC-514 that selectively inhibits IKKβ in the non-canonical pathway (A,B), or CK2i, and inhibitor of the IKK-independent pathway (B), significantly inhibits A. phagocytophilum growth when used in high concentrations and when assessed by quantitative PCR. Error bars are SEM; p-values were calculated comparing to no inhibitor and are listed above each average measurement.