Table 2.
Correlation of Messenger RNA Levels Between Coxsackievirus and Adenovirus Receptor and Inflammatory Markers in Human Carotid Plaques
| Inflammatory Markers | Gene | Pearson r Value | P Value |
|---|---|---|---|
| Cytokines | |||
| TNF-α | TNFA | 0.2122 | .02 |
| IFN-γ | IFNG | 0.02472 | .78 |
| IL-1 β | IL1B | 0.5241 | <.001 |
| IL-2 | IL2 | 0.08896 | .32 |
| IL-6 | IL6 | 0.2385 | .007 |
| IL-4 | IL4 | −0.1683 | .06 |
| IL-5 | IL5 | −0.0368 | .68 |
| IL-9 | IL9 | −0.1354 | .13 |
| IL-10 | IL10 | 0.3465 | <.001 |
| Chemokines and receptors | |||
| MCP-1 | CCL2 | 0.465 | <.001 |
| RANTES | CCL5 | 0.3258 | <.001 |
| CCR2 | CCR2 | 0.4518 | <.001 |
| CCR5 | CCR5 | 0.6766 | <.001 |
| CCR7 | CCR7 | 0.3976 | <.001 |
| Growth factors | |||
| TGF-β1 | TGFB1 | 0.5662 | <.001 |
| TGF- α | TGFA | 0.3581 | <.001 |
| IGF-1 | IGF1 | 0.3001 | <.001 |
| PDGF-A | PDGFA | −0.2335 | .008 |
| PDGF-B | PDGFB | 0.3694 | <.001 |
| PDGF-C | PDGFC | −0.2293 | .01 |
| PDGF-D | PDGFD | −0.3218 | <.001 |
| Matrix/degradation | |||
| MMP-2 | MMP2 | −0.09967 | .27 |
| MMP-9 | MMP9 | 0.6777 | <.001 |
| TIMP-1 | TIMP1 | 0.5481 | <.001 |
| Sulfatase 2 | SULF2 | 0.479 | <.001 |
| Apoptosis | |||
| Caspase 3 | CASP3 | 0.4494 | <.001 |
| Caspase 7 | CASP7 | 0.2185 | .01 |
| Caspase 9 | CASP9 | 0.05095 | .57 |
| BCL-2 | BCL2 | −0.2384 | .007 |
| BMP-4 | BMP4 | −0.2571 | .004 |
Significant cutoff level: P < .05.
Abbreviations: BCL, B-cell lymphoma; BMP, bone morphogenetic protein; IFN, interferon; IGF, insulinlike growth factor; IL-1 β (etc), interleukin 1β (etc); MCP, monocyte chemoattractant protein; MMP, matrix metalloproteinase; PDGF, platelet-derived growth factor; TGF, transforming growth factor; TIMP, tissue inhibitor of metalloproteinase; TNF, tumor necrosis factor.