Table 4.

Optimization Model Performance of Top Predictors of Composite End-Stage Liver Disease

Top Predictor Metabolites	AUC	Sensitivity, %	Specificity, %	Positive Likelihood Ratio	Negative Likelihood Ratio
SM(37:1), PC(32:0), LPC(16:0)	0.84	63	83	3.9	0.43
LPC(15:0), PC(32:0), Cer(41:1)	0.84	55	85	3.78	0.52
LPC(15:0), SM(37:1), PC(32:0)	0.84	65	88	5.71	0.39
TCA, PC(32:0), LPC(16:0)	0.84	68	80	3.5	0.39
PC(32:0), LPC-O(16:1), DG(39:0)	0.84	65	83	4	0.41
LPC(20:4), PC(32:0), Val	0.84	62	90	6.33	0.42
LPC(15:0), PC(32:0), Cer(43:1)	0.84	63	83	3.9	0.43
LPC(15:0), PC(32:0), DG(39:0)	0.84	68	81	3.82	0.38
LPC(15:0), PC(32:0), SM(39:1)	0.84	59	83	3.6	0.49
LPC(15:0), TCA, Val	0.84	68	83	4.2	0.37

Abbreviations: AUC, area under the curve; Cer, ceramide; DG, diacylglycerol; LPC, lysophosphatidylcholine; PC, phosphatidylcholine; SM, sphingomyelin; TCA, taurocholic acid.