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. 2020 Nov;223(5):624–664. doi: 10.1016/j.ajog.2020.06.004

Figure 7.

Figure 7

The estrobolome plays a central role in health and disease through the gut microbiota-estrogen axis

Dysbiosis of gut microbiota may induce systemic inflammation and interferes with estrogen metabolism and receptor activation in estrogen-regulated organs, influencing neurocognition, metabolism, and the onset of gynecologic diseases and infertility.

Reprinted from Baker et al.203

Critchley. Menstruation: science and society. Am J Obstet Gynecol 2020.