Table 1.

Multivariate Cox regression analysis of overall survival with the benefit score and other covariates in different cohorts.

Cohort	Covariates	HR	95% CI	P-value
Van Allen cohort	Age	1.00	0.99–1.02	0.629
	Sex
	Male	0.73	0.45–1.18	0.200
	Stage
	IV	4.20	1.31–13.5	0.016*
	Benefit score
	Low	2.16	1.13–4.12	0.020*
Riaz cohort	Mutation Subtype
	BRAF	0.90	0.40–2.04	0.802
	NF1	1.16	0.32–4.16	0.822
	RAS	0.68	0.27–1.73	0.420
	Prior treatment
	Yes	0.89	0.44–1.78	0.738
	Benefit score
	Low	2.31	0.89–6.01	0.085
Miao cohort	Age	1.01	1.00–1.03	0.135
	Sex
	Male	0.77	0.45–1.32	0.344
	Benefit score
	Low	1.30	0.79–2.14	0.308

HR, Hazard Ratio; CI, Confidence Interval; *indicates statistical significance.